ABSTRACT. Escherichia coli strain Nissle has been used as a probiotic and therapeutic agent for over a century. Reports suggest that Nissle protects mice from enterohemorrhagic E. coli (EHEC) O157:H7 strains; however, mice are not very susceptible to O157:H7 and are not accurate models for O157:H7 infection in humans. We read with interest the publication by Nougayrède and coworkers who described that Escherichia coli strain Nissle 1917 (EcN) is mutagenic by means of its expressed colibactin . The contribution of this work on the biological activity of colibactin is of high significance and increases our knowledge on this enigmatic toxin. In this paper a review of the researches on the role of Escherichia coli strain Nissle 1917 (EcN) in gastrointestinal diseases was presented. EcN is a non-pathogenic strain of the Enterobacteriaceae family, which has probiotic properties. In a number of studies conducted among humans and experimenta …
Among the gram-negative microorganisms with probiotic properties, Escherichia coli strain Nissle 1917 (briefly EcN) is probably the most intensively investigated bacterial strain today. Since nearly 100 years, the EcN strain is used as the active pharmaceutical ingredient in a licensed medicinal pro …

methods have found that probiotic E. coli Nissle 1917 (EcN) may inhibit biofilm formation of other E. coli strains and outcompete their growth. However, the exact mechanism of biofilm inhibition has yet to be elucidated. Using the EcN and E. coli K12 MG1655 (K12) strains, we investigated biofilm inhibition using a biofilm quantification assay.

2. [Elafin-expressing probiotic Escherichia coli Nissle 1917 protects against experimental colitis]. Liu ZL; Wang WH; Liu Y; Wu T; Teng GG Zhonghua Yi Xue Za Zhi; 2021 Dec; 101(46):3819-3824. PubMed ID: 34895424 [No Abstract] 3. Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity.
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